Antioxidant, Phenolic Compounds Concentration, Xanthine Oxidase and Tyrosinase Inhibitory Activities of Pleurotus cornucopiae

Pleurotus cornucopiae has been widely used in nutritional and medicinal purposes. This study was initiated to screen the antioxidant activities, tyrosinase inhibitory effects on the fruiting bodies of P. cornucopiae extracted with acetone, methanol and hot water. The antioxidant activities were performed on β-carotene-linoleic acid, reducing power, DPPH, ferrous ions chelating abilities, and xanthine oxidase. In addition to this, phenolic compounds were also analyzed. The acetonic, methanolic and hot water extracts showed the similar pattern of β-carotene-linoleic acid inhibition. The acetonic extract (8 mg/ml) showed a significantly high reducing power of 1.86 as compare to other extracts. The scavenging effects on DPPH radicals, the acetonic extract was more effective than other extracts. The strongest chelating effect was obtained from the methanolic extract as compare to tested synthetic antioxidant. Gallic acid, protocatechuic acid, chlorogenic acid, vanillin, ferulic acid, naringin, naringenin, hesperetin, formononetin and biochanin-A were detected in acetonitrile and 0.1N hydrochloric acid (5:1) solvent extract. Xanthine oxidase and tyrosinase inhibitory activities of the acetonic, methanolic, and hot water P. cornucopiae extracts increased with increasing concentration. The results suggested that fruiting bodies of P. cornucopiae can be used to developed nutraceutical products, which can play significant roles in providing good nutrition and improving human health.